Human rod cGMP-gated cation channel gene maps to 4p12 [yields] centromere by chromosomal in situ hybridization

Journal Article · Thu Apr 01 00:00:00 EST 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1187· OSTI ID:6332971

Griffin, C A; Ding, Chang Lin; Jabs, E W; Hawkins, A L; Li, Xiang; Levine, M A ^[1]

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1. Johns Hopkins School of Medicine, Baltimore, MD (United States)

Phototransduction is mediated by cGMP, a second messenger that gates a cation channel in the rod outer segment membrane. The level of cGMP in photoreceptor cells is regulated by cGMP phosphodiesterase (PDE), a G-protein-coupled enzyme that is stimulated by light activation of rhodopsin. The cGMP PDE has two catalytic units, alpha and beta, a third subunit, gamma, is inhibitory, and when released facilitates activation of PDE activity. Illumination of vertebrate photoreceptor cells produces transient hyperpolarization due to the closure of a cGMP-gated channel in the rod outer segment membrane. In the dark, photoreceptors are depolarized as the cGMP-gated channels are opened. The retinal rod cGMP channel is a member of a growing family of ligand-gated channels that are regulated by a direct interaction with cyclic nucleotides. The gene encoding the human retinal rod cGMP channel has been cloned recently and preliminarily localized to chromosome 4 using somatic cell hybrid panels. The authors report here confirmation of the mapping to chromosome 4 and refine the map location by chromosomal in situ hybridization. 8 refs., 1 fig.

• OSTI ID: 6332971
• Journal Information: Genomics; (United States), Vol. 16:1; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HUMAN CHROMOSOMES
MAPPING
MEMBRANE PROTEINS
GENES
RETINA
GUANOSINE
VISION
AROMATICS
AZAARENES
BODY
BODY AREAS
CHROMOSOMES
EYES
FACE
HEAD
HETEROCYCLIC COMPOUNDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROTEINS
PURINES
RIBOSIDES
SENSE ORGANS
550400* - Genetics