Evoked trigeminal nerve potential in chronic trichloroethylene intoxication
Results of a study of trigeminal nerve impairment resulting from trichloroethylene intoxication by the somatosensory-evoked potential method reveal three kinds of abnormalities: increased stimulation voltage, excessive latency delay with morphological abnormalities, and excessive graph amplitude. These abnormalities confirm clinical disturbance (hypesthesia of the trigeminal nerve area) and open debate about the real mechanism of trichloroethylene neurotoxicity. Industrial intoxication by solvents, particularly trichloroethylene, is common. We have conducted a study of 188 workers chronically exposed to trichloroethylene and have confirmed the selective neurological disturbances of this intoxication in the trigeminal nerve (20%) (3, 10). We utilized a new experimental method, developed for studies of chronic intoxications effecting the median nerve (5, 8), of recording the somatosensory evoked potential following stimulation of the trigeminal nerve (4, 6, 7). The workers in this study were selected following clinical evaluation of their facial sensitivity and trigeminal nerve reflexes. In this paper we present our preliminary results on 11 workers, 9 suffering effects of intoxication and 2 controls.
- Research Organization:
- Service de Medecine Interne et Toxicologie, C.H.R. de Grenoble, France
- OSTI ID:
- 6323381
- Journal Information:
- J. Toxicol., Clin. Toxicol.; (United States), Vol. 19:4
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CHLORINATED ALIPHATIC HYDROCARBONS
BIOLOGICAL EFFECTS
TOXICITY
NERVES
SENSITIVITY
BIOELECTRICITY
BIOLOGICAL PATHWAYS
CHEMICAL INDUSTRY
MORPHOLOGICAL CHANGES
OCCUPATIONAL SAFETY
PERSONNEL
ELECTRICITY
HALOGENATED ALIPHATIC HYDROCARBONS
INDUSTRY
NERVOUS SYSTEM
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
SAFETY
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
551000 - Physiological Systems
550800 - Morphology