Preparation of tritium-labeled optical isomers of amino acids by ligand exchange chromatography on polyacrylamide sorbent containing L-phenylalanine groupings

Journal Article · Tue Nov 01 00:00:00 EST 1988 · Sov. Radiochem. (Engl. Transl.); (United States)

OSTI ID:6288398

Zolotarev, Yu A; Penkina, V I; Dostavalov, I N; Myasoedov, N F

Tritium-labeled optically active amino acids are obtained by resolving racemates of the corresponding amino acids by chromatography on a chiral polyacrylamide sorbent, filled with copper ions. The chiral sorbent is obtained by the action of formaldehyde and L-phenylalanine on a Biogel P-4 polyacrylamide gel in an alkaline medium. Data are given on the ligand exchange chromatography of amino acids on this sorbent, depending on the degree of filling of the sorbent by copper ions and the concentration of the eluent. Conditions were selected for the quantitative resolution of racemates of amino acids and examples are given of a preparative obtaining of tritium labeled optical isomers of amino acids.

• OSTI ID: 6288398
• Journal Information: Sov. Radiochem. (Engl. Transl.); (United States), Vol. 30:2; Other Information: Translated from Radiokhimiya; 30: No. 2, 243-247(Mar-Apr 1988)
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
AMINO ACIDS
LABELLING
ISOMERS
OPTICAL ACTIVITY
TRITIUM
ISOTOPIC EXCHANGE
TRITIUM COMPOUNDS
ION EXCHANGE CHROMATOGRAPHY
ADSORBENTS
CHEMICAL PREPARATION
COPPER COMPOUNDS
FORMALDEHYDE
GELS
LIGANDS
PHENYLALANINE
POLYAMIDES
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHROMATOGRAPHY
COLLOIDS
DISPERSIONS
HYDROGEN ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC POLYMERS
POLYMERS
RADIOISOTOPES
SEPARATION PROCESSES
SYNTHESIS
TRANSITION ELEMENT COMPOUNDS
YEARS LIVING RADIOISOTOPES
400703* - Radiochemistry & Nuclear Chemistry- Radioisotope Production