In vivo inactivation of lysozyme by ozone

Journal Article · Mon Jan 01 00:00:00 EST 1968 · J. Bacteriol.; (United States)

OSTI ID:6287223

Holzman, R S; Gardner, D E; Coffin, D L

Mice or rabbits were exposed to various doses of O/sub 3/ or NO/sub 2/. Lysozyme concentration in lung lavages decreased linearly with increasing O/sub 3/ dose (5 ppM x 3 hr reduced activity 30%) but returned to normal (linearly) within 12 hr post-exposure. Exposure increased pulmonary heterophils, decreased macrophages (no effect on peritoneal cell mixture which is principally heterophils), and decreased the rate of release of lysozyme from pulmonary and peritoneal cells. There was no effect of 30 ppM NO/sub 2/.

• OSTI ID: 6287223
• Journal Information: J. Bacteriol.; (United States), Vol. 96
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LYSOZYME
INACTIVATION
NITROGEN DIOXIDE
BIOLOGICAL EFFECTS
OZONE
MICE
RABBITS
ANIMALS
CHALCOGENIDES
ENZYMES
GLYCOSYL HYDROLASES
HYDROLASES
MAMMALS
NITROGEN COMPOUNDS
NITROGEN OXIDES
OXIDES
OXYGEN COMPOUNDS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)