Quantitative aspects of 1-norepinephrine induced pathologic changes: a study in normal dogs
The effects of constant rate intravenous infusions of norepinephrine were studied in 28 normal dogs, sedated with morphine. The range of dose rates in this experiment was from 0.5 to 15 mcg/min/kg. Blood levels of epinephrine and norepinephrine were determined in 12 animals up to 10 hours during constant rate infusions. The heart rate and blood pressure were recorded in frequent intervals. The reflex bradycardia was reversed in the animals by prolonged infusions of one or more mcg/min/kg of norepinephrine. Tachycardia and arrhythmia were regularly present in the animals that developed myocardial lesions. Death occurred due to cardiac arrest, massive cerebral hemorrhage or pulmonary edema in the animals infused with 10 mcg/min/kg for 1/2 to 3 hours, or 5 mcg/min/kg for 6 hours. Post mortem examination was performed on all animals. The tissue changes were described and correlated with dosage rate and blood catecholamine levels. 17 references, 8 figures.
- Research Organization:
- National Naval Medical Center, Bethesda, MD (USA)
- OSTI ID:
- 6267776
- Report Number(s):
- CONF-590801-1; ON: DE85900322
- Resource Relation:
- Conference: 1. symposium on the catecholamines in cardiovascular pathology, Burlington, VT, USA, 23 Aug 1959; Other Information: Portions are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
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