Effects of morphine and naloxone on feline colonic transit

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(89)90587-0· OSTI ID:6255662

Krevsky, B; Libster, B; Maurer, A H; Chase, B J; Fisher, R S

The effects of endogenous and exogenous opioid substances on feline colonic transit were evaluated using colonic transit scintigraphy. Naloxone accelerated emptying of the cecum and ascending colon, and filling of the transverse colon. Endogenous opioid peptides thus appear to play a significant role in the regulation of colonic transit. At a moderate dose of morphine cecum and ascending colon transit was accelerated, while at a larger dose morphine had no effect. Since naloxone, a relatively nonspecific opioid antagonist, and morphine, a principally mu opioid receptor agonist, both accelerate proximal colonic transit, a decelerating role for at least one of the other opioid receptors is inferred.

• Research Organization: Temple Univ., Philadelphia, PA (USA)
• OSTI ID: 6255662
• Journal Information: Life Sci.; (United States), Vol. 44:13
• Country of Publication: United States
• Language: English

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