Synthesis of (/sup 18/F)-5-fluorouridine (F-18-5-FUR) as a probe for measuring RNA synthesis and tumor growth rates in vivo

Conference · Mon Jan 01 00:00:00 EST 1979

OSTI ID:6228573

Shiue, C Y; Fowler, J S; MacGregor, R R; Wolf, A P

A method for the rapid synthesis of high specific activity of (/sup 18/F)-5-fluorouridine is described. The /sup 20/Ne(d,..cap alpha..)/sup 18/F nuclear reaction is used to produce high specific activity, anhydrous (/sup 18/F)-F/sub 2/ at the Brookhaven National Laboratory 60'' cyclotron. Fluorination of 2',3',5'-tri-0-acetyluridine with (/sup 18/F)-F/sub 2/ in glacial acetic acid at room temperature followed by hydrolysis with sodium methoxide in methanol gives (/sup 18/F)-5-fluorouridine with a radiochemical yield of 5 to 7% in a synthesis time of 90 minutes from EOB. The compound is required for the study of RNA synthesis and tumor growth rates in vivo.

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• DOE Contract Number: EY-76-C-02-0016
• OSTI ID: 6228573
• Report Number(s): BNL-25851; CONF-790321-7; TRN: 79-014027
• Resource Relation: Conference: 2. international symposium on radiopharmaceuticals, Seattle, WA, USA, 18 Mar 1979
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
FLUOROURACILS
SYNTHESIS
NEOPLASMS
GROWTH
PROBES
RNA
BIOSYNTHESIS
BROOKHAVEN CYCLOTRON
FLUORINE 18
MEASURING METHODS
NUCLEAR REACTION KINETICS
ACCELERATORS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
AZINES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CYCLIC ACCELERATORS
CYCLOTRONS
DISEASES
DRUGS
FLUORINE ISOTOPES
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
ISOCHRONOUS CYCLOTRONS
ISOTOPES
KINETICS
LIGHT NUCLEI
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIOISOTOPES
REACTION KINETICS
URACILS
550200* - Biochemistry
550201 - Biochemistry- Tracer Techniques