Proliferative activity of benign human prostate, prostatic adenocarcinoma and seminal vesicle evaluated by thymidine labeling

Journal Article · Wed Dec 01 00:00:00 EST 1982 · J. Urol.; (United States)

OSTI ID:6224100

Meyer, J S; Sufrin, G; Martin, S A

The thymidine labeling index (TLI) was measured in vitro in the epithelium and stroma of benign prostate glands and seminal vesicles and in the epithelium of prostatic adenocarcinomas. The mean epithelial TLI of normal peripheral (posterior) prostatic zone was 0.12 percent, and that of the normal central (deep) zone was 0.11 percent. Mean normal stromal TLI's were 0.08 percent and 0.06 percent, respectively. The mean TLI of epithelium in nodular hyperplasia was 0.31 percent, which differs significantly from normal epithelium (p less than 0.05), and the mean stromal TLI was also increased (0.16 percent, p less than 0.1). The mean TLI of prostatic adenocarcinomas was 0.90 percent (range 0.14 to 3.90 percent) which was significantly higher than for either normal epithelium (p less than 0.001) or epithelium of nodular hyperplasia (p less than 0.05). Trends of increasing TLI with increasing histologic grades and increasing nuclear size and numbers of nucleoli were not significant. The data support participation of both epithelial and stromal proliferation in nodular hyperplasia, and indicate a low basal proliferative rate in normal prostatic glands. The low TLI's of prostatic adenocarcinomas relative to other malignancies are consistent with their frequently slowly progressive course. The very low proliferative rate of seminal vesicular epithelium (mean TLI 0.02 percent) may account for the rarity of seminal vesicular carcinomas.

• Research Organization: Department of Pathology, Jewish Hospital of St. Louis, Missouri
• OSTI ID: 6224100
• Journal Information: J. Urol.; (United States), Vol. 128:6
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
PATHOLOGY
EPITHELIUM
AUTORADIOGRAPHY
PROSTATE
BIOLOGICAL PATHWAYS
CARCINOGENESIS
CELL PROLIFERATION
THYMIDINE
TRITIUM COMPOUNDS
TUMOR CELLS
ANIMAL CELLS
ANIMAL TISSUES
AZINES
BODY
DISEASES
GLANDS
HETEROCYCLIC COMPOUNDS
LABELLED COMPOUNDS
MALE GENITALS
NEOPLASMS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PYRIMIDINES
RIBOSIDES
TISSUES
550601* - Medicine- Unsealed Radionuclides in Diagnostics