Malignant mesothelioma induced by asbestos and zeolite in the mouse peritonenal cavity

Journal Article · Mon Oct 01 00:00:00 EDT 1984 · Environ. Res.; (United States)

OSTI ID:6214556

Suzuki, Y; Kohyama, N

The carcinogenicity of asbestos (amosite and chrysotile) and zeolite (fibrous erionite, mordenite, and synthetic zeolite 4A) were studied in the peritoneum of 586 BALB/C male mice after a single intraperitoneal or intraabdominal wall injection. Tumors developed in 93 of 394 animals (23.6%) treated with asbestos or fibrous erionite 7 months or more after administration. All of the induced peritoneal tumors were intimately associated with marked peritoneal fibrosis, in which asbestos or erionite fibers were regularly detected. Histopathologically, 83 of 93 were consistent with malignant mesotheliomas. Other tumors consisted of 6 plasmacytomas, 1 histiocytoma, 1 liposarcoma, 1 osteosarcoma, and 1 adenocarcinoma of the pancreas. Two of the cases of mesotheliomas were associated with plasmacytoma. In many instances, the primary site of the mesotheliomas seemed to be multiple, the favorite sites being the omentum, mesentery, serosae of the gastrointestinal and genital organs, the diaphragm, the capsule of the liver and spleen, and the abdominal wall peritoneum. In addition to the 93 peritoneal tumors, 3 extraperitoneal tumors (1 fibrosarcoma and 2 rhabdomyosarcomas) were induced by amosite which was probably accidentally injected into the extraperitoneal connective tissue and the striated muscle tissue of the abdominal wall, respectively. These three tumors were also intimately associated with focal fibrosis in which amosite fibers were detected. Among the three different types of zeolite, only fibrous erionite showed striking carcinogenicity and marked fibrogenicity. The erionite-induced mesotheliomas were similar to those induced by asbestos in exhibiting long latency, in gross appearance, in histology, and in close association with fibrosis.

• Research Organization: Mount Sinai School of Medicine of the City Univ. of New York, New York
• OSTI ID: 6214556
• Journal Information: Environ. Res.; (United States), Vol. 35:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ASBESTOS
CARCINOGENESIS
DIAPHRAGM
NEOPLASMS
FEMALE GENITALS
GASTROINTESTINAL TRACT
LIVER
MALE GENITALS
PERITONEUM
PATHOLOGY
SPLEEN
ZEOLITES
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DIGESTIVE SYSTEM
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ION EXCHANGE MATERIALS
MAMMALS
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MEMBRANES
MINERALS
MUSCLES
NUMERICAL DATA
ORGANS
PATHOGENESIS
PATHOLOGICAL CHANGES
RODENTS
SEROUS MEMBRANES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)