Validation of a simplified carbon-14-urea breath test for routine use for detecting Helicobacter pylori noninvasively
- Univ. of Ulm (West Germany)
A carbon-14 ({sup 14}C) urea breath test for detecting Helicobacter pylori with multiple breath sampling was developed. Carbon-14-urea (110 kBq) administered orally to 18 normal subjects and to 82 patients with Helicobacter infection. The exhaled {sup 14}C-labeled CO{sub 2} was trapped at 10-min intervals for 90 min. The total {sup 14}C activity exhaled over 90 min was integrated and expressed in %activity of the total dose given. In normals, a mean of 0.59% +/- 0.24% was measured, resulting in an upper limit of normal of 1.07%. In 82 patients, a sensitivity of 90.2%, a specificity of 83.8%, and a positive predictive value of 90.2% was found. The single probes at intervals of 40-60 min correlated best with the integrated result, with r ranging from 0.986 to 0.990. The test's diagnostic accuracy did not change at all when reevaluated with the 40-, 50-, or 60-min sample data alone. Thus, the {sup 14}C-urea breath test can be applied routinely as a noninvasive, low-cost and one-sample test with high diagnostic accuracy in detecting Helicobacter pylori colonization.
- OSTI ID:
- 6213220
- Journal Information:
- Journal of Nuclear Medicine; (USA), Vol. 31:12; ISSN 0161-5505
- Country of Publication:
- United States
- Language:
- English
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BACTERIAL DISEASES
DIAGNOSIS
ACCURACY
CARBON 14 COMPOUNDS
CARBON DIOXIDE
PATIENTS
TRACER TECHNIQUES
UREA
VALIDATION
AMIDES
CARBON COMPOUNDS
CARBON OXIDES
CARBONIC ACID DERIVATIVES
CHALCOGENIDES
DISEASES
INFECTIOUS DISEASES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
TESTING
550601* - Medicine- Unsealed Radionuclides in Diagnostics