Boron neutron capture therapy of intracerebral rat gliosarcomas
- Brookhaven National Laboratory, Upton, NY (USA)
The efficacy of boron neutron capture therapy (BNCT) for the treatment of intracerebrally implanted rat gliosarcomas was tested. Preferential accumulation of 10B in tumors was achieved by continuous infusion of the sulfhydryl borane dimer, Na4(10)B24H22S2, at a rate of 45-50 micrograms of 10B per g of body weight per day from day 11 to day 14 after tumor initiation (day 0). This infusion schedule resulted in average blood 10B concentrations of 35 micrograms/ml in a group of 12 gliosarcoma-bearing rats and 45 micrograms/ml in a group of 10 similar gliosarcoma-bearing rats treated by BNCT. Estimated tumor 10B levels in these two groups were 26 and 34 micrograms/g, respectively. On day 14, boron-treated and non-boron-treated rats were exposed to 5.0 or 7.5 MW.min of radiation from the Brookhaven Medical Research Reactor that yielded thermal neutron fluences of approximately 2.0 x 10(12) or approximately 3.0 x 10(12) n/cm2, respectively, in the tumors. Untreated rats had a median postinitiation survival time of 21 days. Reactor radiation alone increased median postinitiation survival time to 26 (5.0 MW.min) or 28 (7.5 MW.min) days. The 12 rats that received 5 MW.min of BNCT had a median postinitiation survival time of 60 days. Two of these animals survived greater than 15 months. In the 7.5 MW.min group, the median survival time is not calculable since 6 of the 10 animals remain alive greater than 10 months after BNCT. The estimated radiation doses to tumors in the two BNCT groups were 14.2 and 25.6 Gy equivalents, respectively. Similar gliosarcoma-bearing rats treated with 15.0 or 22.5 Gy of 250-kilovolt peak x-rays had median survival times of only 26 or 31 days, respectively, after tumor initiation.
- OSTI ID:
- 6210719
- Journal Information:
- Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 87:24, Issue 24; ISSN 0027-8424
- Country of Publication:
- United States
- Language:
- English
Similar Records
Uptake of [sup 10]B in gliosarcomas following the injection of gluthathione monoethyl ester and sulfhydryl borane
A nude rat model for neutron capture therapy of human intracerebral melanoma
Related Subjects
BRAIN
SARCOMAS
NEUTRON CAPTURE THERAPY
EXPERIMENTAL NEOPLASMS
RADIATION DOSES
RATS
SURVIVAL TIME
ANIMALS
BODY
CENTRAL NERVOUS SYSTEM
DISEASES
DOSES
MAMMALS
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NEUTRON THERAPY
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
RADIOTHERAPY
RODENTS
THERAPY
VERTEBRATES
550603* - Medicine- External Radiation in Therapy- (1980-)