Tritium labeling of organic compounds by NHaY zeolite catalyzed exchange with tritiated water and their analysis by /sup 3/H NMR
The principle of using small amounts of high activity water in an otherwise water-sensitive catalytic system has previously been employed with Lewis acid labeling catalysts. The advantages of such procedures include the relative simplicity of handling tritiated water and its low cost compared with alternatives such as tritium gas and tritiated benzene. No vacuum techniques are necessary, and the activity of the product is limited only by the specific activity of the small aliquot of HTO used as isotope source. The reactants, organic (0.1 g), zeolite (25 mg), and tritiated water (5 ..mu..L, 40 mCi/mL) were sealed in a glass ampule and heated to 175/sup 0/C for the desired reaction time. Products were analyzed by radiogas chromatography and /sup 3/H NMR spectroscopy. The results show that the procedure represents a highly efficient method of tritiation of most aromatic compounds. Since the molar ratio of organic compound to water was high, equilibrium represents virtually 100% incorporation of the tritium utilized in the experiment.
- Research Organization:
- Univ. of New South Wales, Kensington, Australia
- OSTI ID:
- 6205020
- Journal Information:
- J. Am. Chem. Soc.; (United States), Vol. 103:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
AROMATICS
LABELLING
ORGANIC COMPOUNDS
TRITIUM
ISOTOPIC EXCHANGE
ZEOLITES
CATALYTIC EFFECTS
NMR SPECTRA
SPECTROSCOPY
TRITIUM OXIDES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHALCOGENIDES
HYDROGEN ISOTOPES
INORGANIC ION EXCHANGERS
ION EXCHANGE MATERIALS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MATERIALS
MINERALS
NUCLEI
ODD-EVEN NUCLEI
OXIDES
OXYGEN COMPOUNDS
RADIOISOTOPES
SPECTRA
TRITIUM COMPOUNDS
YEARS LIVING RADIOISOTOPES
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
400303 - Organic Chemistry- Isotope Exchange & Isotope Separation- (-1987)