Transplacental diffusion and blood flow of gravid bovine uterus
Electromagnetic blood flow transducers and uterine arterial, uterine venous, umbilical venous, fetal femoral arterial, and fetal femoral venous catheters were implanted in 11 cows on day 161 +/- 4 of gestation. Antipyrine (0.66 M) plus NaCl (0.16 M) dissolved in deuterium oxide (D/sub 2/O), or H/sub 2/O, was infused at a constant rate into the fetal femoral vein catheter. Concentrations of antipyrine and D/sub 2/O in uterine arterial and venous blood and antipyrine in fetal arterial and umbilical venous blood, as well as middle uterine arterial blood flow (electromagnetic transducer), were determined. Antipyrine and D/sub 2/O gave similar estimates (steady-state diffusion method) of gravid uterine blood flow. In addition, the slope of the regression of D/sub 2/O on antipyrine estimates was not different from one. Electromagnetic transducers gave estimates of uterine blood flow that were 32-42% of those obtained with steady-state diffusion but were correlated with estimates obtained by use of both antipyrine and D/sub 2/O. The transplacental clearance rate of antipyrine was similar (per kg placenta) to that observed in ewes. It was suggested that the maternal and fetal microvasculatures of the bovine placenta could have a concurrent arrangement with vascular shunts or maldistribution of flows, as has been suggested for the ewe.
- Research Organization:
- Dept. of Agriculture, Clay Center, NE
- OSTI ID:
- 6191026
- Journal Information:
- Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ANTIPYRINE
BLOOD CHEMISTRY
HEAVY WATER
PLACENTA
BLOOD FLOW
DYNAMIC FUNCTION STUDIES
UTERUS
COWS
DIFFUSION
PREGNANCY
WATER
ANIMALS
ANTIPYRETICS
AZOLES
BODY
CATTLE
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DOMESTIC ANIMALS
DRUGS
FEMALE GENITALS
FETAL MEMBRANES
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
MAMMALS
MEMBRANES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PYRAZOLES
PYRAZOLINES
RUMINANTS
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques