Normal sister chromatid exchange frequencies during growth of a transplantable murine myeloid leukemia
Frequencies of sister chromatid exchange (SCE) were analyzed in normal and coexisting leukemic cells harvested from the bone marrow of mice 10, 15, 18, and 21 days after transplantation of myeloid leukemic cells. These posttransplantation stages correspond to no abnormal physical or clinical symptoms (day 10) through the terminal stage of leukemia (day 21). The data indicate that the SCE frequencies in normal cells of leukemic mice did not differ from those in normal cells of normal mice. Furthermore, the frequencies in the coexisting normal and leukemic cells remained statistically constant throughout the posttransplantation period. It is concluded from this study that spontaneous cellular SCE frequencies may not be altered by the presence or growth of leukemic cells. 15 references, 1 figure, 1 table.
- Research Organization:
- Oak Ridge National Lab., TN
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 6181503
- Journal Information:
- Cancer Genet. Cytogenet.; (United States), Vol. 14
- Country of Publication:
- United States
- Language:
- English
Similar Records
Evaluation of sister chromatid exchange and cytotoxicity in murine tissues in vivo and lymphocytes in vitro following methyl isocyanate exposure
Cytogenetic effects of inhaled benzene in murine bone marrow: induction of sister chromatid exchanges, chromosomal aberrations, and cellular proliferation inhibition in DBA/2 mice