A simple method for measuring zinc absorption in man using a short-lived isotope (/sup 69m/Zn)
Using a short-lived isotope of zinc (/sup 69m/Zn) with a half-life of 13.9 hour, we have developed a simple test of zinc absorption. After an oral dose of isotope (50 ..mu..Ci) with 2 mg of elemental zinc a plasma appearance curve was constructed from radioactivity determined in blood samples taken sequentially over 8 hours. Two weeks later an iv dose of isotope (25 ..mu..Ci) was administered and a plasma disappearance curve was constructed. Absorption was calculated by computer analysis of appearance and disappearance curves using a deconvolution programme. Mean absorption in five normal subjects was 61% (range 41 to 79%). In three subjects given food with, or 1 hour before the isotope, absorption was delayed and reduced to less than 20% of the oral dose at 8 hours. This test of zinc absorption is simple to perform and, because the isotope was a short half-life, has the advantage of subjecting patients to only limited radiation.
- Research Organization:
- Univ. of Manchester, England
- OSTI ID:
- 6150214
- Journal Information:
- Am. J. Clin. Nutr.; (United States), Vol. 33:4
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ZINC
METABOLISM
ZINC 69
RADIONUCLIDE KINETICS
ABSORPTION
INGESTION
ISOMERS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
METALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
RADIOISOTOPES
ZINC ISOTOPES
560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)
550500 - Metabolism