Evaluation of toluene exposure via drinking water on levels of regional brain biogenic monoamines and their metabolites in CD-1 mice

Journal Article · Mon Oct 01 00:00:00 EDT 1990 · Ecotoxicology and Environmental Safety; (USA)

DOI:https://doi.org/10.1016/0147-6513(90)90056-B· OSTI ID:6139922

Hsieh, G C; Sharma, R P; Parker, R D; Coulombe, Jr, R A ^[1]

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1. Utah State Univ., Logan (USA)

Toluene, a potentially neurotoxic substance, is found in trace amounts in groundwater. Adult male CD-1 mice were continuously fed drinking water ad libitum containing 0, 17, 80, and 405 mg/liter toluene. After a 28-day treatment, animals were tested for endogenous levels of the biogenic monoamines norepinephrine (NE), dopamine (DA), and serotonin (5-HT) and their respective metabolites, 3-methoxy-4-hydroxymandelic acid (VMA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA), in six discrete brain regions. The maximum toluene-induced increases of biogenic amines and their metabolites generally occurred at a toluene concentration of 80 mg/liter. In the hypothalamus, a major NE-containing compartment, the concentrations of NE significantly increased by 51, 63, and 34% in groups dosed with 17, 80, and 405 mg/liter, respectively. Significant increases of NE were also observed in the medulla oblongata and midbrain. Concomitantly, concentrations of VMA increased in various brain regions. Concentrations of DA were significantly higher in the corpus striatum and hypothalamus. Alterations in levels of DA metabolites, DOPAC and HVA, were marginal. Toluene significantly increased concentrations of 5-HT in all dissected brain regions, except cerebellum, and increased the 5-HIAA levels in the hypothalamus, corpus striatum, and cerebral cortex.

• OSTI ID: 6139922
• Journal Information: Ecotoxicology and Environmental Safety; (USA), Vol. 20:2; ISSN 0147-6513
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DOPAMINE
BIOSYNTHESIS
DRINKING WATER
CONTAMINATION
METABOLITES
NORADRENALINE
SEROTONIN
TOLUENE
METABOLISM
BRAIN
INGESTION
MICE
WATER POLLUTION
ADRENAL HORMONES
ALKYLATED AROMATICS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
INTAKE
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PHENOLS
POLLUTION
POLYPHENOLS
PYRROLES
RADIOPROTECTIVE SUBSTANCES
RODENTS
SYMPATHOMIMETICS
SYNTHESIS
TRYPTAMINES
VERTEBRATES
WATER
560300* - Chemicals Metabolism & Toxicology