Rapid and complete urinary elimination of (/sup 14/C)-5-hydroxymethyl-2-furaldehyde administered orally or intravenously to rats

Journal Article · Thu Jan 01 00:00:00 EST 1987 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398709531052· OSTI ID:6124964

Germond, J E; Philippossian, G; Richli, U; Bracco, I; Arnaud, M J

5-Hydroxymethyl-2-furaldehyde (HMF), is a major product of sugar degradation found in food and solutions used in parenteral nutrition. Labeled (/sup 14/C)HMF was synthesized by dehydration of (/sup 14/C)fructose on ion-exchange resin and administered per os (po) and intravenously (iv) to rats. Metabolic balance of radioactivity demonstrated that HMF or its metabolites are rapidly eliminated in the urine with a recovery of 95-100% after 24 h. Literature reported, in some cases, 50% retention in the body. HMF was completely converted to two metabolites, which have been identified by nuclear magnetic resonance (NMR) and mass spectroscopy (MS) as 5-hydroxymethyl-2-furoic acid and N-(5-hydroxymethyl-2-furoyl)glycine. Administration of high doses of HMF showed a similar rapid elimination, but a proportional reduction of the amount of the glycine conjugate produced. Whole-animal-body autoradiography confirm that shortly after administration radioactive material was present in the liver but was mostly in the kidney and the bladder. The only significant difference between po and iv administration was the presence of a higher level of radioactive material in the brain of iv-treated rats.

• Research Organization: Nestle Research Centre, Nestec Ltd., Vevey, Switzerland
• OSTI ID: 6124964
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 22:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
METABOLISM
TISSUE DISTRIBUTION
AUTORADIOGRAPHY
CARBON 14 COMPOUNDS
DOSE-RESPONSE RELATIONSHIPS
GLYCINE
INTRAVENOUS INJECTION
MASS SPECTROSCOPY
METABOLITES
NUCLEAR MAGNETIC RESONANCE
ORAL ADMINISTRATION
RATS
AMINO ACIDS
ANIMALS
CARBOXYLIC ACIDS
DISTRIBUTION
INJECTION
INTAKE
LABELLED COMPOUNDS
MAGNETIC RESONANCE
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
RESONANCE
RODENTS
SPECTROSCOPY
VERTEBRATES
550501* - Metabolism- Tracer Techniques