Evaluation of 90-day inhalation toxicity of petroleum and oil-shale diesel fuel marine (DFM). Final technical report, November 1977-January 1985
Subchronic 90-day inhalation toxicity studies were conducted to compare the toxicity of petroleum and oil-shale-derived diesel fuel marine (DFM). Beagle dogs, Fischer 344 rats, and C57BL/6 mice were continuously exposed to DFM at concentrations of 50 mg/cu. m and 300 mg/cu. m. Unexposed controls were also maintained. All dogs and a portion of each rodent group were sacrificed and examined at exposure termination. The remaining rodents were held for observation up to 21 months postexposure. Male rats exposed to DFM for 90 days developed nephrotoxic changes characterized by hyaline degeneration, necrosis, and intratubular cysts. Subsequently, male rats exposed to 300 mg/cu. m DFM developed mineralization and papillary hyperplasia. These postexposure renal changes were generally less severe in male rats exposed to 50 mg/cu. m Shale DFM and were absent in male rats exposed to 50 mg/cu. m Petroleum DFM. Female rats as well as dogs and mice exposed to DFM were free of significant renal damage. Mild reductions in body-weight gains and erythrocyte parameters were also noted in male rats exposed to DFM. Neither material produced significant tumor formation in any species tested. The results of this study are consistent with the effects noted in other hydrocarbon-fuel toxicity studies. Comparison of the effects observed in these studies with petroleum or shale suggest only minor differences between the two materials.
- Research Organization:
- California Univ., Dayton, OH (USA)
- OSTI ID:
- 6072150
- Report Number(s):
- AD-A-202722/5/XAB
- Country of Publication:
- United States
- Language:
- English
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02 PETROLEUM
04 OIL SHALES AND TAR SANDS
DIESEL FUELS
TOXICITY
HYDROCARBONS
OIL SHALES
PETROLEUM PRODUCTS
CONTROL
DAMAGE
DOGS
ERYTHROCYTES
FEMALES
FUELS
INHALATION
KIDNEYS
MALES
MICE
MINERALIZATION
NECROSIS
NEOPLASMS
PROGRESS REPORT
RATS
REDUCTION
RODENTS
ANIMALS
BIOLOGICAL MATERIALS
BITUMINOUS MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBONACEOUS MATERIALS
CHEMICAL REACTIONS
DISEASES
DOCUMENT TYPES
ENERGY SOURCES
FOSSIL FUELS
INTAKE
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
020900 - Petroleum- Environmental Aspects
041000 - Oil Shales & Tar Sands- Environmental Aspects