Vanadium-mediated lipid peroxidation in microsomes from human term placenta

Journal Article · Tue Nov 01 00:00:00 EST 1988 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF02021021· OSTI ID:6043787

Byczkowski, J Z; Wan, B; Kulkarni, A P

Vanadium is considered an essential element present in living organisms in trace amounts but it is toxic when introduced in excessive doses to animals and humans. Vanadium compounds are extensively used in modern industry and occupational exposure to high doses of vanadium is quite common. In pregnant mice, vanadium accumulates preferentially in the placenta and to lower extent in fetal skeleton and mammary gland during exposure to radioactive vanadium. Accumulation of vanadium in fetoplacental unit may present threat to the fetus by interacting with enzymes and ion-transporting systems in membranes. It is also possible that accumulation of vanadium with its concomitant reduction to vanadyl may lead to lipid peroxidation, followed by damage to biological membranes, lysosomal enzymes release and destruction of placental tissue. To explore some of these possibilities the authors decided to examine whether vanadate can undergo redox cycling in microsomes from human term placenta (HTP) that can lead to lipid peroxidation.

• Research Organization: Univ. of South Florida, Tampa (USA)
• OSTI ID: 6043787
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Vol. 41:5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LIPIDS
OXIDATION
OXYGEN
UPTAKE
VANADIUM COMPOUNDS
BIOLOGICAL EFFECTS
BIOCHEMISTRY
MICROSOMES
PLACENTA
VANADATES
WOMEN
ANIMALS
CELL CONSTITUENTS
CHEMICAL REACTIONS
CHEMISTRY
ELEMENTS
FEMALES
FETAL MEMBRANES
MAMMALS
MAN
MEMBRANES
NONMETALS
ORGANIC COMPOUNDS
ORGANOIDS
OXYGEN COMPOUNDS
PRIMATES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology