Renal hyperconcentration of /sup 99m/Tc-HEDP in experimental acute tubular necrosis. [Comparison of renal distribution of /sup 99m/Tc-HEDP, -DMSA, and -DTPA in rabbits]

Conference · Tue May 01 00:00:00 EDT 1979 · Radiology; (United States)

OSTI ID:6037260

Lavelle, K J; Park, H M; Moseman, A M; Lewis, S

The effect of transient renal ischemia on renal concentration and distribution of /sup 99m/Tc-HEDP, /sup 99m/Tc-DMSA, and /sup 99m/Tc-DTPA was compared in rabbits with acute tubular necrosis. Scintigrams were obtained after injection in normal rabbits or ones with unilateral or bilateral ischemia. /sup 99m/Tc-HEDP concentration in ischemic tissue was 8 to 18 times normal 1 to 4 hrs after injection, and the resulting images delineated the morphological changes in the ischemic kidneys more accurately than those obtained with DMSA or DTPA. Calcium concentration in the ischemic kidneys increased sixfold. /sup 99m/Tc-HEDP may be useful in evaluation of renal failure secondary to tubular injury.

• Research Organization: Indiana Univ., Indianapolis
• OSTI ID: 6037260
• Journal Information: Radiology; (United States), Vol. 131:2; Conference: 25. annual meeting of the Society of Nuclear Medicine, Anaheim, CA, USA, 27 Jun 1978
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
BLOOD FLOW
MEASURING METHODS
CARBOXYLIC ACID ESTERS
RADIOPHARMACEUTICALS
DTPA
HDEHP
ISCHEMIA
DIAGNOSIS
KIDNEYS
DYNAMIC FUNCTION STUDIES
SCINTISCANNING
NECROSIS
TISSUE DISTRIBUTION
TECHNETIUM 99
UROGENITAL SYSTEM DISEASES
COMPARATIVE EVALUATIONS
INTRAVENOUS INJECTION
ISOMERIC NUCLEI
LABELLED COMPOUNDS
RABBITS
AMINO ACIDS
ANEMIAS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CHELATING AGENTS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DRUGS
ESTERS
HEMIC DISEASES
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PHOSPHORIC ACID ESTERS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPONSE MODIFYING FACTORS
SYMPTOMS
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
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560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
551000 - Physiological Systems
550900 - Pathology