DNA rearrangement in human follicular lymphoma can involve the 5' or the 3' region of the bcl-2 gene

Journal Article · Sun Mar 01 00:00:00 EST 1987 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.84.5.1329· OSTI ID:6023055

Tsujimoto, Y; Bashir, M M; Givol, I; Cossman, J; Jaffe, E; Croce, C M

In most human lymphomas, the chromosome translocation t(14;18) occurs within two breakpoint clustering regions on chromosome 18, the major one at the 3' untranslated region of the bcl-2 gene and the minor one at 3' of the gene. Analysis of a panel of follicular lymphoma DNAs using probes for the first exon of the bcl-2 gene indicates that DNA rearrangements may also occur 5' to the involved bcl-2 gene. In this case the IgH locus and the bcl-2 gene are found in an order suggesting that an inversion also occurred during the translocation process. The coding region of the bcl-2 gene, however, are left intact in all cases of follicular lymphoma studied to date.

• Research Organization: Wistar Institute, Philadelphia, PA
• OSTI ID: 6023055
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 84:5
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
LYMPHOMAS
DNA SEQUENCING
GENETICS
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
DNA
ELECTROPHORESIS
GENE REGULATION
IMMUNOGLOBULINS
PHOSPHORUS 32
TUMOR CELLS
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGY
DAYS LIVING RADIOISOTOPES
DISEASES
GLOBULINS
ISOTOPES
LIGHT NUCLEI
MUTATIONS
NEOPLASMS
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PHOSPHORUS ISOTOPES
PROTEINS
RADIOISOTOPES
STRUCTURAL CHEMICAL ANALYSIS
550201* - Biochemistry- Tracer Techniques