DNA probes for papillomavirus strains readied for cervical cancer screening

Journal Article · Fri Nov 18 00:00:00 EST 1988 · JAMA, J. Am. Med. Assoc.; (United States)

DOI:https://doi.org/10.1001/jama.1988.03410190021002· OSTI ID:5982268

Merz, B

New Papillomavirus tests are ready to come to the aid of the standard Papanicolauo test in screening for cervical cancer. The new tests, which detect the strains of human papillomavirus (HPV) most commonly associated with human cervical cancer, are designed to be used as an adjunct to rather than as a replacement for the Papanicolaou smears. Their developers say that they can be used to indicated a risk of developing cancer in women whose Papanicolaou smears indicate mild cervical dysplasia, and, eventually, to detect papillomavirus infection in normal Papanicolaou smears. The rationale for HPV testing is derived from a growing body of evidence that HPV is a major factor in the etiology of cervical cancer. Three HPV tests were described recently in Chicago at the Third International Conference on Human Papillomavirus and Squamous Cervical Cancer. Each relies on DNA probes to detect the presence of papillomavirus in cervical cells and/or to distinguish the strain of papillomavirus present.

• OSTI ID: 5982268
• Journal Information: JAMA, J. Am. Med. Assoc.; (United States), Vol. 260:18
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CARCINOMAS
DIAGNOSIS
VIRUSES
HYBRIDIZATION
CARCINOGENESIS
DNA
PHOSPHORUS 32
SCREENING
UROGENITAL SYSTEM DISEASES
UTERUS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DISEASES
FEMALE GENITALS
ISOTOPES
LIGHT NUCLEI
MICROORGANISMS
NEOPLASMS
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PARASITES
PATHOGENESIS
PHOSPHORUS ISOTOPES
RADIOISOTOPES
550401* - Genetics- Tracer Techniques