Effects of chelating agents on oral uptake and renal deposition and excretion of cadmium. [Mice]
The gastrointestinal absorption, transport, tissue deposition and excretion of cadmium was studied in adult male mice given a single oral LD/sub 50/ dose of /sup 109/Cd-labeled CdCl/sub 2/ alone or in combination with nitrilotriacetic acid (NTA), sodium tripolyphosphate (STPP) or ethylenediaminetetraacetic acid (EDTA). Blood, intestinal mucosa, liver and kidneys were analyzed for /sup 109/Cd at different times after exposure and the influence of the chelating agents on Cd binding to metallothionein and other tissue ligands was also studied. The effect of different chelating agents on acute cadmium toxicity and metabolism seemed to be due to changes in the stability of the administered chelate complexes, due to variation in pH and to the availability of metal binding ligands such as metallothionein in vivo. NTA, STPP and EDTA had no effect on the metabolism or toxicity of cadmium after long-term low dose oral exposure. 43 references, 4 tables, 9 figures.
- Research Organization:
- National Institute of Environmental Medicine, Stockholm, Sweden
- OSTI ID:
- 5975198
- Journal Information:
- Environ. Health Perspect.; (United States), Vol. 54
- Country of Publication:
- United States
- Language:
- English
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CADMIUM
METABOLISM
CADMIUM 109
TISSUE DISTRIBUTION
CHELATING AGENTS
BIOLOGICAL EFFECTS
METALLOTHIONEIN
BIOCHEMICAL REACTION KINETICS
BLOOD
CHEMICAL ANALYSIS
CHEMICAL BONDS
CHRONIC EXPOSURE
EDTA
EXCRETION
EXPERIMENTAL DATA
INTESTINES
KIDNEYS
LIVER
MICE
MUCOUS MEMBRANES
NTA
ORAL ADMINISTRATION
PH VALUE
RATS
UPTAKE
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CADMIUM ISOTOPES
CARBOXYLIC ACIDS
CLEARANCE
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
GLANDS
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOTOPES
KINETICS
MAMMALS
MATERIALS
MEMBRANES
METALLOPROTEINS
METALS
NUCLEI
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
REACTION KINETICS
RODENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)