Teratogenicity of 2,3,7,8-tetrachlorodibenzofuran in the mouse

Journal Article · Sun Jan 01 00:00:00 EST 1984 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398409530584· OSTI ID:5968508

Hassoun, E; d'Argy, R; Dencker, L

2,3,7,8-Tetrachlorodibenzofuran (TCDBF) was administered in single doses (0.1-0.8 mg/kg body weight) intraperitoneally to pregnant C57BL mice on d 10, 11, 12, or 13 of gestation. A dose-dependent increase was observed in the frequency of fetal resorptions and fetal death, especially in the earlier stages (d 10-11). Cleft palate and hydronephrosis as well appeared in a dose-dependent manner, with a peak in sensitivity after administration on d 11-12. TCDBF given at a dose level of 0.1 mg/kg body weight on d 12 of gestation (only dose- and stage-tested) produced a marked thymic hypoplasia as well. A few cases of general hydrops occurred. The pattern of malformations and time of sensitivity corresponded well to that observed earlier after administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; ED50 approx. = 25 ..mu..g/kg) and 3,3',4,4'-tetrachloroazoxybenzene (TCAOB; ED50 approx. = 6 mg/kg), two congeners of TCDBF, indicating common mechanisms of action of this family of compounds. Ornithine decarboxylase (ODC) is an important enzyme in cell proliferation and growth with a high activity in embryonic tissues. Liver ODC activity has previously been found to be stimulated by TCDD in weanling mice. However, this enzyme was not found to be stimulated in fetal and placental tissues, but slightly in maternal kidney after treatment with TCDBF in teratogenic doses. It is possible that the ODC activity increases under certain conditions only, on administration of TCDD and its congeners. 40 references, 3 tables, 3 figures.

• Research Organization: Uppsala Univ., Sweden
• OSTI ID: 5968508
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 14:2-3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHLORINATED AROMATIC HYDROCARBONS
TERATOGENESIS
DECARBOXYLASES
ENZYME ACTIVITY
MICE
CONGENITAL MALFORMATIONS
ADULTS
CELL PROLIFERATION
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
FETAL MEMBRANES
FETUSES
GROWTH
INTRAPERITONEAL INJECTION
KIDNEYS
LIVER
SENSITIVITY
AGE GROUPS
ANIMALS
AROMATICS
BODY
CARBON-CARBON LYASES
CARBOXY-LYASES
DATA
DIGESTIVE SYSTEM
ENZYMES
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
INFORMATION
INJECTION
INTAKE
LYASES
MALFORMATIONS
MAMMALS
MEMBRANES
NUMERICAL DATA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)