Problems in establishing norm values for nickel and chromium concentrations in human pulmonary tissue
In 15 random autopsies, nickel (Ni) and chromium (Cr) were determined quantitatively by atomic absorption spectrometry (AAS) in human lung tissue to evaluate norm values. None of the deceased persons had had an occupational exposure to Cr or Ni or their compounds. In all, 22 tissue samples were taken from each lung at specific topographical anatomical locations. The analytical procedure is described in detail. The results showed substantial variation in concentrations both within a single lung and also between individuals. Median values found were 204 ng/g for Cr and 25.6 ng/g for Ni. Topographical concentrations of Cr and Ni were 1.3-1.9 times higher in the upper lung areas. In view of the variability in metal concentration, analysis of only one part of lung tissue is not sufficient for determining the content of the entire lung. The evaluation of norm values is an important precondition for appraisal of Cr and Ni accumulation in human pulmonary tissue that may be due to occupational exposure.
- Research Organization:
- Univ. of Erlangen-Nurnberg, Germany, F.R.
- OSTI ID:
- 5956040
- Journal Information:
- Am. J. Ind. Med.; (United States), Vol. 12:1
- Country of Publication:
- United States
- Language:
- English
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CHROMIUM
METABOLISM
TISSUE DISTRIBUTION
NICKEL
ABSORPTION SPECTROSCOPY
AUTOPSY
LUNGS
MAN
OCCUPATIONAL EXPOSURE
ANIMALS
BODY
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
ELEMENTS
MAMMALS
METALS
ORGANS
PRIMATES
RESPIRATORY SYSTEM
SPECTROSCOPY
TRANSITION ELEMENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology