The EGG 57-CO B-12 absorption test, in the evaluation of patients with low serum B-12

Conference · Wed May 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5939934

Sinow, R M; Carmel, R; Siegel, M E

The Schilling Test (ST) is the standard test for diagnosing vitamin B-12 malabsorption (MA). However, patients with subtle gastric dysfunction may have normal ST, but impaired absorption of B-12 given with food. The authors have adapted an Egg B-12 Absorption Test (EBAT) in which 57-Co cyanocobalamin (57-Co B-12) is mixed with scrambled egg to evaluate this phenomenon in patients with low serum B-12, normal ST and possible subtle MA. Lyophilized egg yolk is reconstituted and mixed with 57-Co- B-12 of equal dose to that of ST. The authors studied 46 individuals: 13 controls, 5 patients with known pernicious anemia (PA), in addition to 28 patients with low serum B-12 levels and normal ST. ST/EBAT ratios were calculated. Twenty-eight test patients excreted 13.3% on ST and 3.5% on EBAT. Mean ST/EBAT ratio was 8.2 (1.4-35.9). Five had EBAT results in the PA range (<1%) and ST/EBAT ratios (14.4-35.9) that were significantly elevated. This group is also evaluated with pepsinogen I/II ratios, gastric analysis, deoxyuridine suppression tests, anti intrinsic factor, and antiparietal cell antibodies. The authors' results indicate that the EBAT can differentiate between PA and non PA patients, and that some patients with low serum B-12 levels and normal ST may, in fact, have subtle MA. The EBAT, combined with ST/EBAT ratio, may provide a means for identifying this group of patients.

• Research Organization: USC School of Medicine, Los Angeles, CA
• OSTI ID: 5939934
• Report Number(s): CONF-850611-; TRN: 87-039204
• Journal Information: J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
COBALT 57
DIAGNOSTIC USES
METABOLIC DISEASES
DIAGNOSIS
VITAMIN B-12
INTESTINAL ABSORPTION
METABOLISM
DEOXYURIDINE
DIGESTION
DYNAMIC FUNCTION STUDIES
INGESTION
LABELLING
NUTRITIONAL DEFICIENCY
ORAL ADMINISTRATION
PATIENTS
PEPSIN
STOMACH
ABSORPTION
ACID PROTEINASES
ANTIMETABOLITES
AZINES
BETA DECAY RADIOISOTOPES
BODY
COBALT ISOTOPES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENZYMES
GASTROINTESTINAL TRACT
HEMATINICS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
HYDROLASES
HYDROXY COMPOUNDS
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDE HYDROLASES
PYRIMIDINES
RADIOISOTOPES
RIBOSIDES
UPTAKE
URACILS
USES
VITAMIN B GROUP
VITAMINS
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550901 - Pathology- Tracer Techniques