Brain oxygen utilization measured with O-15 radiotracers and positron emission tomography: Generation of metabolic images
The author recently described and validated a method for the measurement of regional cerebral oxygen extraction (E) and metabolic rate (CMRO/sub 2/) using 0-15 labeled radiotracers and positron emission tomography. The equation for the calculation of E from measured PET data is mathematically complex, involving numerical integration of two convolution operations. Its direct application to PET images on a pixel-by-pixel basis is computationally burdensome, because of the large amount of spatial data to be analyzed. The authors have developed a simplification of their operational equation which permits efficient generation of quantitative metabolic images. The terms involving convolution operations are replaced by second-order polynomials, the coefficients of which need only be evaluated once. With this approach, metabolic maps of E and CMRO/sub 2/ can be generated for 7 tomographic slices in less than 15 sec. With the development of complex tracer kinetic models for PET, solution of the operational equations relating PET measurements of local radioactivity to the physiologic variable of interest may be time-consuming computationally. The simplification of the equation for the calculation of E provides a solution for a specific example of this more general problem.
- Research Organization:
- Washington Univ. School of Medicine, St. Louis, MO
- OSTI ID:
- 5939568
- Report Number(s):
- CONF-850611-; TRN: 87-039232
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BRAIN
BIOCHEMICAL OXYGEN DEMAND
METABOLISM
POSITRON COMPUTED TOMOGRAPHY
RESPIRATION
OXYGEN 15
DIAGNOSTIC USES
IMAGE PROCESSING
ANATOMY
BASAL METABOLISM
CEREBRAL CORTEX
DATA ANALYSIS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
CEREBRUM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
OXYGEN ISOTOPES
PROCESSING
RADIOISOTOPES
TOMOGRAPHY
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550501 - Metabolism- Tracer Techniques
550801 - Morphology- Tracer Techniques