Metabolic tissue characterization in patients with acute myocardial infarction with positron tomography
Identification of myocardium at risk in acute myocardial infarction (AMI) is important for patient management. The authors previously demonstrated in animals that reversible tissue injury can be identified with PET and tracers of metabolism. To characterize reginal metabolism in AMI, 12 patients were studied <72 hours after onset of symptoms with positron tomography (PET). Regional wall motion (WM) was assessed by 2D echocardiography at the time of the PET study and again 6 weeks later. Myocardial blood flow (MBF) and exogenous glucose utilization were measured with N-13 ammonia and F-18 deoxyglucose in 5 LV segments in each patient and compared to regional WM. MBF was decreased in 29 LV segments. The irreversible tissue injury can be identified early in patients with AMI. PET frequently reveals persistent glucose utilization in ''infarcted'' myocardium when studied within 72 hours after AMI. Persistent exogenous glucose utilization detected by PET early after AMI can identify viable but jeopardized myocardium and may predict subsequent functional recovery.
- Research Organization:
- UCLA School of Medicine, Los Angeles, CA
- OSTI ID:
- 5936118
- Report Number(s):
- CONF-850611-; TRN: 87-039565
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
Similar Records
Identification and differentiation of resting myocardial ischemia and infarction in man with positron computed tomography, /sup 18/F-labeled fluorodeoxyglucose and /sup 13/N ammonia
Recovery of glucose metabolism in reperfused canine myocardium demonstrated by positron-CT (PCT)
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
FLUORODEOXYGLUCOSE
METABOLISM
MYOCARDIAL INFARCTION
DIAGNOSIS
MYOCARDIUM
BLOOD FLOW
DYNAMIC FUNCTION STUDIES
POSITRON COMPUTED TOMOGRAPHY
GLUCOSE
HEART
LABELLING
ALDEHYDES
ANTIMETABOLITES
BODY
CARBOHYDRATES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
HEXOSES
MONOSACCHARIDES
MUSCLES
ORGANIC COMPOUNDS
ORGANS
SACCHARIDES
TOMOGRAPHY
550602* - Medicine- External Radiation in Diagnostics- (1980-)
550501 - Metabolism- Tracer Techniques