Intravenous elimination and percutaneous absorption of topically applied thioguanine-14c (nsc-752) in yorkshire white pigs. Final report, 22 June-14 October 1977

Technical Report · Wed Mar 15 00:00:00 EST 1978

OSTI ID:5932640

Skierkowski, P; Murphy, J C; Watson, E S; Folk, R M; Pavkov, K L

The distribution and elimination of intravenously administered Thioguanine-14C (NSC-752) was studied in female, weanling, Yorkshire, white pigs. Approximately one-half the radioactivity was eliminated in the urine in the first six hours, and the majority was eliminated by the end of the 24 hours after intravenous administration. After 96 hours (4 days) an average of 84% was eliminated via the urine. This elimination percentage was then utilized to determine the amount of Thioguanine-14C absorbed after topical application. Among the whole organs sampled, kidney, liver and spleen had the highest specific activities of radioactivity. Intestine and bone marrow samples had the highest specific activity levels of the random tissues sampled. The absorption of the Thioguanine-14C after topical application was minimal with approximately 0.77% of the administered dose being absorbed at the end of 192 hours (8 days). Significant levels of radioactivity were also detected in skin surrounding the site of application.

• Research Organization: Battelle Columbus Toxicology Program Office, McLean, VA (USA); Mississippi Univ., University (USA). Research Inst. of Pharmaceutical Sciences
• DOE Contract Number: N01-CM-4-3746
• OSTI ID: 5932640
• Report Number(s): PB-290434; TRN: 79-019510
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
ANTINEOPLASTIC DRUGS
EXCRETION
SKIN ABSORPTION
TISSUE DISTRIBUTION
CARBON 14 COMPOUNDS
INTRAVENOUS INJECTION
SWINE
TRACER TECHNIQUES
URINE
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CLEARANCE
DISTRIBUTION
DOMESTIC ANIMALS
DRUGS
INJECTION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
UPTAKE
VERTEBRATES
WASTES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550501 - Metabolism- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques