Conserved chromosomal positions of dual domains of the ets protooncogene in cats, mice, and humans
The mammalian protooncogene homologue of the avian v-ets sequence from the E26 retrovirus consists of two sequentially distinct domains located on different chromosomes. Using somatic cell hybrid panels, the authors have mapped the mammalian homologue of the 5' v-ets-domain to chromosome 11 (ETS1) in man, to chromosome 9 (ets-1) in mouse, and to chromosome D1 (ETS1) in the domestic cat. The mammalian homologue of the 3' v-ets domain was similarly mapped to human chromosome 21 (ETS2), to mouse chromosome 16 (Ets-2), and to feline chromosome C2 (ETS2). Both protooncogenes fell in syntenic groups of homologous linked loci that were conserved among the three species. The occurrence of two distinct functional protooncogenes and their conservation of linkage positions in the three mammalian orders indicate that these two genes have been separate since before the evolutionary divergence of mammals.
- Research Organization:
- National Center Institute, Frederick, MD
- OSTI ID:
- 5931303
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 83:6
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CHROMOSOMES
AUTORADIOGRAPHY
ONCOGENES
GENETIC MAPPING
CATS
DNA-CLONING
HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE
LYMPHOCYTES
MAN
MICE
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CLONING
CONNECTIVE TISSUE CELLS
ENZYMES
GENES
GLYCOSYL TRANSFERASES
LEUKOCYTES
MAMMALS
MAPPING
MATERIALS
PENTOSYL TRANSFERASES
PRIMATES
RODENTS
SOMATIC CELLS
TRANSFERASES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550201 - Biochemistry- Tracer Techniques