Selenium and vitamin E deficiencies do not enhance lung inflammation from cigarette smoke in the hamster

Journal Article · Tue Feb 01 00:00:00 EST 1983 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:5893816

Niewoehner, D E; Peterson, F J; Hoidal, J R

The early lung inflammatory response to cigarette smoke may be oxidant-mediated. We fed Syrian hamsters a diet deficient in selenium and vitamin E to determine whether impairment of the lung's antioxidant defenses might worsen inflammation induced by cigarette smoke. After 8 wk, cigarette-smoke-exposed animals had characteristic inflammatory lesions in the distal airways. Increased numbers of phagocytes, predominantly macrophages, were recovered by lavage and these cells exhibited enhanced oxidative metabolism. Animals fed the deficient diet had profound depletions of selenium and vitamin E, but no alterations in the histologic appearance of smoke-induced inflammatory lesions, in the numbers of phagocytes recruited, or in the oxidative metabolism of these phagocytes. These results suggest that selenium and vitamin E are unimportant in protecting against cigarette-smoke-induced lung injury.

• Research Organization: Pulmonary Section, Veterans Administration Medical Center, Minneapolis, Minnesota
• OSTI ID: 5893816
• Journal Information: Am. Rev. Respir. Dis.; (United States), Vol. 127:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LUNGS
INJURIES
TOBACCO SMOKES
BIOLOGICAL EFFECTS
DIET
HAMSTERS
RESPONSE MODIFYING FACTORS
SELENIUM
VITAMIN E
AEROSOLS
ANIMALS
BODY
COLLOIDS
DISPERSIONS
ELEMENTS
MAMMALS
ORGANS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SEMIMETALS
SMOKES
SOLS
VERTEBRATES
VITAMINS
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)