Cancer of the head and neck in atomic bomb survivors: Hiroshima and Nagasaki, 1957-1976
- Radiation Effects Research Foundation, Hiroshima-Nagasaki, Japan
A search was conducted in Hiroshima and Nagasaki for all cases of cancer of the lip, nose and nasal cavity, accessory sinuses, larynx, and the oral cavity and pharynx with their subdivisions occurring during the period 1957-1976 among a large fixed cohort of atomic bomb survivors. A total of 232 cases were identified, of which 154 (66.4%) were histologically confirmed (definite cases). Among definite cases, cancer of the epiglottis and larynx predominated (31.2%), followed by accessory sinus (24.7%) and tongue (18.8%). Of the 154 definite cases, 141 (91.6%) were squamous-cell carcinomas. Only two sarcomas were identified, neither of which was attributable to radiation exposure. Analysis of both total and definite cases, by both total group and major anatomic site, failed to reveal definite evidence of a radiation relationship. Although a suggestive relationship to radiation dose was found for accessory sinus cancers (P = 0.06) among the definite cases, inconsistencies in the data do not permit the conclusion that the incidence of tumors in this group increased as a result of atomic bomb radiation exposure. The medical literature concerning post-irradiation head and neck tumors is briefly reviewed.
- OSTI ID:
- 5870851
- Journal Information:
- Cancer (Philadelphia); (United States), Vol. 48:10
- Country of Publication:
- United States
- Language:
- English
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A-BOMB SURVIVORS
NEOPLASMS
DELAYED RADIATION EFFECTS
EPIDEMIOLOGY
DIAGNOSIS
NUCLEAR EXPLOSIONS
BIOLOGICAL RADIATION EFFECTS
CARCINOMAS
DATA COMPILATION
HEAD
HIROSHIMA
NAGASAKI
NECK
ASIA
BIOLOGICAL EFFECTS
BODY
BODY AREAS
DATA
DISEASES
EXPLOSIONS
HUMAN POPULATIONS
INFORMATION
JAPAN
NUMERICAL DATA
POPULATIONS
RADIATION EFFECTS
560151* - Radiation Effects on Animals- Man
560160 - Radionuclide Effects
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& Toxicology