Aluminum permeation of the blood-brain barrier occurs primarily across brain capillaries

Conference · Mon Mar 11 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5863448

Allen, D D; Yokel, R A ^[1]

---

1. Univ. of Kentucky, Lexington (United States)

Aluminum has been demonstrated to be neurotoxic and has been implicated in several neurobehavioral disorders. The primary site(s) and mechanism(s) of Al flux across the blood-brain barrier (BBB) have not been elucidated. Aluminum (Al) permeation of the BBB was assessed in male Sprague-Dawley rats. Utilizing the in vivo microdialysis technique, unbound extracellular Al concentrations were ascertained at the two potential sites of flux across the BBB; the choroid plexus and brain capillaries. Microdialysis probes were implanted in the lateral ventricle and in the frontal cortex to elucidate flux across the choroid plexus and brain capillaries, respectively. A microdialysis probe was also implanted in the jugular vein to reveal blood Al concentrations. Aluminum citrate was administered via the femoral vein. Peak frontal cortex and blood Al concentration were seen within the first two 5 minute sampling periods. When concentrations were measurable for lateral ventricle, the peak concentrations were also seen within the first two 5 minute sampling periods. Area under the curve (AUC) (concentrations vs. time to last sample time point) values were calculated using RSTRIP. Brain and cerebrospinal fluid AUCs were divided by blood AUC within animal to calculate tissue/blood ratios (TBRs). Frontal cortex TBRs were significantly higher than those calculated for lateral ventricle. The results indicate that the primary site of Al flux across the BBB occurs at brain capillaries.

• OSTI ID: 5863448
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:4; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALUMINIUM
MEMBRANE TRANSPORT
BLOOD-BRAIN BARRIER
PERMEABILITY
BRAIN
CAPILLARIES
METABOLISM
RATS
TOXICITY
ANIMALS
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
ELEMENTS
MAMMALS
METALS
NERVOUS SYSTEM
ORGANS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology