Concomitant hepatic radiation and intraarterial fluorinated pyrimidine therapy: Correlation of liver scan, liver function tests, and plasma CEA with tumor response

Journal Article · Tue Dec 15 00:00:00 EST 1981 · Cancer (Philadelphia)

DOI:https://doi.org/10.1002/1097-0142(19811215)48:12<2569::AID-CNCR2820481205>3.0.CO;2-%23· OSTI ID:5842364

Lokich, J. ^[1]; Kinsella, T.; Perri, J.; Malcolm, A.; Clouse, M.

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1. New England Deaconess Hospital, Boston, MA

Sixteen patients with metastatic disease to the liver (12 colorectal and four unknown primary tumors) were treated in a pilot study of hepatic irradiation (2500-3000 rads in 10-12 fractions) delivered concomitantly with continuous short-term intraarterial infusion of 5-fluorouracil (1 g/d) or FUDR (0.5 mg/kg/d) via a percutaneously placed hepatic artery catheter. Abnormal liver function tests, including SGOT, LDH, and alkaline phosphatase, decreased in all patients by day 7-10 of treatment, and other metabolic factors, including serum cholesterol, calcium, albumin, phosphorous, and uric acid, also decreased, often to subnormal levels by termination of treatment (day 15-20). These chemical alterations did not correlate with tumor response in that the identical pattern was observed in responders (ten patients) as well as nonresponders (six patients). Objective determinants of response were assessed by serial monitoring of plasma carcinoembryonic antigen (CEA) and liver scan. In 14 patients with elevated CEA levels, tumor response (nine patients), nonresponse (four patients), and relapse (five patients) was predicted and confirmed by sequential monitoring of CEA. In one patient, a paradoxical decrease in plasma CEA was associated with progressive disease. The liver scan identified all responding patients but was difficult to quantitate and was delayed for months following subjective clinical response and changes in plasma CEA levels.

• OSTI ID: 5842364
• Journal Information: Cancer (Philadelphia), Vol. 48, Issue 12; ISSN 0008-543X
• Publisher: American Cancer Society
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
CHEMOTHERAPY
CORRELATIONS
ENZYME ACTIVITY
LIVER
DYNAMIC FUNCTION STUDIES
RADIOTHERAPY
BIOLOGICAL FUNCTIONS
CARCINOEMBRYONIC ANTIGEN
DIAGNOSIS
DOSE-RESPONSE RELATIONSHIPS
FRACTIONATED IRRADIATION
FUDR
NEOPLASMS
PATIENTS
QUANTITATIVE CHEMICAL ANALYSIS
SCINTISCANNING
ANTI-INFECTIVE AGENTS
ANTIGENS
ANTIMETABOLITES
ANTIMICROBIAL AGENTS
AZINES
BODY
CHEMICAL ANALYSIS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DRUGS
FLUOROURACILS
FUNCTIONS
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IRRADIATION
MEDICINE
NUCLEAR MEDICINE
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RADIOISOTOPE SCANNING
RADIOLOGY
RADIOSENSITIZERS
RIBOSIDES
THERAPY
URACILS
550603* - Medicine- External Radiation in Therapy- (1980-)
550601 - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques