Cardiovascular changes in unanesthetized and ketamine-anesthetized Sprague-Dawley rats exposed to 2. 8-GHz radiofrequency radiation

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Laboratory Animal Science; (USA)

OSTI ID:5799009

Jauchem, J R; Frei, M R ^[1]

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1. United States Air Force School of Aerospace Medicine, Brooks Air Force Base, TX (USA)

Sprague-Dawley rats were exposed to 2.8-GHz radiofrequency radiation, first while unanesthetized and then while anesthetized with ketamine (150 mg/kg.I.M.). Irradiation at a power density of 60 mW/cm2 (whole-body average specific absorption rate of approximately 14 W/kg) was conducted for sufficient duration to increase colonic temperature from 38.5 to 39.5 degrees C. The time required for the temperature increase was significantly longer in the anesthetized state. During irradiation, heart rate increased significantly both with and without anesthesia, while mean arterial blood pressure increased only when the rats were unanesthetized. The heart rate increase in the anesthetized state contrasts with a lack of change in a previous study of Fischer rats. This difference between anesthetized Sprague-Dawley and Fischer rats should be considered when comparing cardiovascular data obtained from these two strains of rats.

• OSTI ID: 5799009
• Journal Information: Laboratory Animal Science; (USA), Vol. 41:1; ISSN 0023-6764
• Country of Publication: United States
• Language: English

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