Pulmonary retention of inhaled diesel particles after prolonged exposures to diesel exhaust
The effect of continuous exposure to diluted diesel exhaust on the pulmonary retention of inhaled diesel particles was studied in male Fischer 344 rats. Test animals were first exposed to clean air or diluted diesel exhaust in exposure chambers at nominal particulate concentrations of 250 micrograms/m/sup 3/ or 6 mg/m/sup 3/ for 20 hr/day, 7 days/week, for periods lasting from 7 to 112 days, followed by a nose-only exposure to /sup 14/C-tagged diesel particles for 45 min. At preselected time intervals after the radioactive exposure, the /sup 14/C-activities in the lungs of groups of four animals were measured to determine the clearance of the /sup 14/C-diesel particles up to 1 year. The pulmonary retention of the radioactive diesel particles was greater in animals which had been preexposed to diesel exhaust. The slower alveolar clearance of particle-laden macrophages and leukocytes can be described by a normal biphasic clearance model.
- Research Organization:
- General Motors Technical Center, Warren, MI
- OSTI ID:
- 5776208
- Journal Information:
- Fundam. Appl. Toxicol.; (United States), Vol. 4:4
- Country of Publication:
- United States
- Language:
- English
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CARBON 14 COMPOUNDS
INHALATION
LUNG CLEARANCE
EXHAUST GASES
BIOLOGICAL EFFECTS
LUNGS
RETENTION FUNCTIONS
PARTICULATES
CHRONIC EXPOSURE
DIESEL ENGINES
LEUKOCYTES
MACROPHAGES
RATS
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CLEARANCE
CONNECTIVE TISSUE CELLS
ENGINES
EXCRETION
FLUIDS
FUNCTIONS
GASEOUS WASTES
GASES
HEAT ENGINES
INTAKE
INTERNAL COMBUSTION ENGINES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
ORGANS
PARTICLES
PHAGOCYTES
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
VERTEBRATES
WASTES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)