Evaluation of energy spectral information in nuclear imaging and investigation of protein binding of radiogallium. Progress report, October 1, 1980-November 30, 1983
The gamma camera-computer interface was modified to allow the computer to accept both a spatial and energy address from each incoming photon. We have used this system to study the effect of scatter on measurement of ventricular function by ejection fraction (EF). Our preliminary results indicate that energy windowing, which decreases scatter fraction, increases recorded ejection fraction, EF. These results indicate that energy resolution and windowing must be considered when normal EF values are established, patients are studied on different instruments, or old equipment is replaced with newer model cameras. We have also further elucidated possible mechanisms by which Gallium-67 localizes in inflammatory lesions and tumors. Gallium-67 can transfer from transferrin and lactoferrin to ferritin. Transfer can be influenced by a number of mediators. We have studied the localization of Gallium-67 in a benign non-infected bone lesion (fracture). Although Gallium-67 uptake in such lesions appears on imaging to be less than /sup 99m/Tc-MDP uptake, the actual quantitative uptake in bone is identical. We are currently conducting studies of Gallium-67 uptake in an osteomyelitis model in rabbits in order to determine if such uptake accurately reflects the effect of antibiotic treatment.
- Research Organization:
- Yale Univ., New Haven, CT (USA)
- DOE Contract Number:
- AC02-78EV04625
- OSTI ID:
- 5764782
- Report Number(s):
- DOE/EV/04625-T3; ON: DE83014765; TRN: 83-019353
- Country of Publication:
- United States
- Language:
- English
Similar Records
Evaluation of energy spectral information in nuclear imaging and investigation of protein binding of radiogallium. Progress report, October 1, 1980-September 30, 1981
Evaluation of energy spectral information in nuclear imaging and investigation of protein binding of cationic radionuclides by lactoferrin. Comprehensive progress report, October 1, 1977-September 30, 1980
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
GALLIUM 67
BIOLOGICAL LOCALIZATION
UPTAKE
GAMMA CAMERAS
IMAGE PROCESSING
NUCLEAR MEDICINE
RESEARCH PROGRAMS
SKELETON
RADIONUCLIDE KINETICS
DYNAMIC FUNCTION STUDIES
HEART
INFLAMMATION
NEOPLASMS
OSTEOMYELITIS
RABBITS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CAMERAS
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGICAL CHANGES
PROCESSING
RADIOISOTOPES
SKELETAL DISEASES
SYMPTOMS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)