Fibronectin concentrations in lung lavage fluid after inhalation exposure to low levels of metals
Groups of rabbits were exposed by inhalation to chlorides of cobalt, nickel, and manganese as well as to tri- and hexavalent chromium at metal concentrations ranging from 0.4 to 3.9 mg/m/sup 3/ for 1-4 months (5 days/week, 6 hr/day). Fibronectin content and lysozyme (muramidase) activity in lavage fluid were measured after all treatments and in alveolar macrophages after treatment with nickel chloride. In the lavage fluid no marked changes were seen in fibronectin content and lysozyme activity after exposure to tri- or hexavalent chromium or manganese. Nickel exposure significant decreased the lysozyme activity in the lavage fluid and in the macrophages whereas the fibronectin content was unchanged in the lavage fluid and significantly increased in the macrophages. Both fibronectin content and lysozyme activity were increased markedly in the lavage fluid after cobalt exposure.
- Research Organization:
- National Defense Research Institute, Umea, Sweden
- OSTI ID:
- 5764704
- Journal Information:
- Environ. Res.; (United States), Vol. 43:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
COBALT COMPOUNDS
CHLORIDES
TOXICITY
GLUCOPROTEINS
BIOCHEMICAL REACTION KINETICS
MANGANESE COMPOUNDS
NICKEL COMPOUNDS
BODY FLUIDS
COMPARATIVE EVALUATIONS
ENZYME ACTIVITY
INHALATION
LAVAGE
LUNGS
LYSOZYME
MACROPHAGES
RABBITS
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BODY
CARBOHYDRATES
CHLORINE COMPOUNDS
CONNECTIVE TISSUE CELLS
ENZYMES
GLYCOSYL HYDROLASES
HALIDES
HALOGEN COMPOUNDS
HYDROLASES
INTAKE
KINETICS
MAMMALS
MATERIALS
O-GLYCOSYL HYDROLASES
ORGANIC COMPOUNDS
ORGANS
PHAGOCYTES
PROTEINS
REACTION KINETICS
RESPIRATORY SYSTEM
SACCHARIDES
SOMATIC CELLS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology