Drinking water and health. Volume 9: Selected issues in risk assessment
This is the ninth volume in the series Drinking Water and Health issued by the Safe Drinking Water Committee of the Board on Environmental Studies and Toxicology of the National Research Council. It focuses on two important current topics: the first part examines the possible uses of DNA adducts in risk assessment, and the second part examines the issue of multiple toxic chemicals in drinking water and the assessment of their health risks. As described in Part 1, studies of DNA have been rapidly refined and developed in the past few years. The Executive Summary of Part 1 summarizes the findings of the subcommittee. Chapter 1 describes where and how DNA adducts are formed and repaired; what is known of their relationship to protein adducts and to exposure to, and toxic effects of, contaminants; and some differences in adduct formation between humans and laboratory animals. The uses and limitations of current techniques for detecting DNA adducts and protein adducts and the outlook for the application of the techniques in toxicity testing, biologic monitoring and epidemiology are described in Chapter 2. Chapter 3 presents the subcommittee's conclusions and recommendations. Part 2 of this volume addresses mixtures of toxic chemicals. Regulatory agencies have used results of studies of single toxicants to form procedures for regulating exposure. But predicting effects of mixtures solely from knowledge of effects of their components can be erroneous. Some agents interact when combined to produce biologic responses different from those expected, and interactions and the magnitude of responses might not be considered properly. Many components of drinking water produce similar biologic effects.
- OSTI ID:
- 5763862
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DRINKING WATER
CONTAMINATION
XENOBIOTICS
TOXICITY
BIOLOGICAL MODELS
CARCINOGENESIS
DNA ADDUCTS
DOSE-RESPONSE RELATIONSHIPS
LABORATORY ANIMALS
MAN
MIXTURES
RECOMMENDATIONS
RISK ASSESSMENT
ADDUCTS
ANIMALS
DISPERSIONS
HYDROGEN COMPOUNDS
MAMMALS
OXYGEN COMPOUNDS
PATHOGENESIS
PRIMATES
VERTEBRATES
WATER
540320* - Environment
Aquatic- Chemicals Monitoring & Transport- (1990-)
560300 - Chemicals Metabolism & Toxicology