Boron neutron capture therapy of brain tumors: Enhanced survival following intracarotid injection of sodium borocaptate with or without blood-brain barrier disruption
Journal Article
·
· International Journal of Radiation Oncology, Biology and Physics
- Ohio State Univ., Columbus, OH (United States); and others
Sodium borocaptate (Na{sub 2}B{sub 12}H{sub 11}SH or BSH) has been used clinically for boron neutron capture therapy (BNCT) of patients with primary brain tumors. The purpose of the present study was to determine if tumor uptake of BSH and efficacy of BNCT could be enhanced in F98 glioma-bearing rats by intracarotid (i.c.) injection of the compound with or without blood-brain barrier disruption (BBB-D). 56 refs., 4 figs., 3 tabs.
- OSTI ID:
- 576199
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Vol. 37, Issue 3; Other Information: PBD: 1 Feb 1997
- Country of Publication:
- United States
- Language:
- English
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