Combination of cis-platinum and bleomycin prior to surgery and/or radiotherapy compared with radiotherapy alone for the treatment of advanced squamous cell carcinoma of the head and neck
Forty-one patients with unresectable Stage IV head and neck squamous cell carcinoma were treated with combined modality therapy (CM) consisting of induction chemotherapy followed by surgery and/or radiotherapy (RT). Treatment and survival results are reported and compared to results obtained in treating 41 historic controls with RT alone. No patient had distant metastases. Patients in the CM group received cis-platinum (DDP) 120 mg/m/sup 2/ on days 1 and 22 with prehydration and mannitol diuresis and bleomycin 15 ..mu../m/sup 2/ as a continuous infusion between days 3-9 started after a 15 ..mu../m/sup 2/ IV push. Patients underwent reendoscopy two weeks after completing chemotherapy to evaluate response. Subsequent surgery and/or radiotherapy were administered depending on tumor resectability after chemotherapy. Induction chemotherapy with DDP and bleomycn infusion followed by surgery and/or radiotherapy appears to be associated with a higher CR rate and prolonged survival compared to RT alone. (JMT)
- Research Organization:
- Boston Veterans Administration Medical Center, MA
- OSTI ID:
- 5742910
- Journal Information:
- Cancer (Philadelphia); (United States), Vol. 50:12
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARCINOMAS
CHEMOTHERAPY
RADIOTHERAPY
COMPARATIVE EVALUATIONS
SIDE EFFECTS
BLEOMYCIN
COBALT 60
EXTERNAL IRRADIATION
GOLD 198
HEAD
NECK
PLATINUM COMPOUNDS
RADIATION SOURCE IMPLANTS
RADIUM
SURGERY
SURVIVAL TIME
ALKALINE EARTH METALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
COBALT ISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELEMENTS
GOLD ISOTOPES
HEAVY NUCLEI
IMPLANTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
METALS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
RADIATION SOURCES
RADIOISOTOPES
RADIOLOGY
THERAPY
TRANSITION ELEMENT COMPOUNDS
YEARS LIVING RADIOISOTOPES
550603* - Medicine- External Radiation in Therapy- (1980-)
550600 - Medicine