Regional effects of ovariectomy and cadmium on bone mineral in ribs from aged female beagles

Conference · Tue Jan 01 00:00:00 EST 1991

OSTI ID:5739105

Hurst, D R ^[1]

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1. Miami Univ., Oxford, OH (USA). Dept. of Zoology

The purpose of this study was to evaluate effects of estrogen depletion and cadmium (Cd) on bone calcium and to determine if these effects were localized in specific regions of ribs. Fourteen female beagles with {sup 45}Ca labeled skeletons were divided into four groups: sham controls (SO{minus}); ovariectomized (OV{minus}); shams exposed to Cd (SO+); ovariecomized exposed to Cd (OV+). Total Cd exposure period was 7 months, including 1 month by capsules and 6 months by drinking H{sub 2}O. Ribs were taken at necropsy from 12 of the 14 dogs, and each rib was quartered. Wet, dry, and ash weights, as well as total Ca and {sup 45}Ca content, were determined for each quarter. Analysis of ribs from control animals demonstrated that a given rib is heterogeneous in composition. One end appears to be less mineralized and more metabolically active than other regions. The OV{minus} and OV+ mid-rib regions had significantly lower dry and ash weights than SO{minus}. Total Ca contents of these same regions were also decreased in the OV{minus} and OV+. The only significant change in Ca/dry and Ca/ash was observed when comparing OV+ to SO{minus}. Analysis of treatment suggests that there are regional effects following ovariectomy increased the loss of bone mineral occurring as a result of ovariectomy. 30 refs., 1 fig.

• Research Organization: Argonne National Lab., IL (USA)
• Sponsoring Organization: USDOE; DOHHS; USDOE, Washington, DC (USA); Department of Health and Human Services, Washington, DC (USA)
• DOE Contract Number: W-31109-ENG-38
• OSTI ID: 5739105
• Report Number(s): ANL/CP-73029; CONF-9103136-5; ON: DE91011839; CNN: ES04 816-01; TRN: 91-018578
• Resource Relation: Conference: 5. national conference on undergraduate research, Pasadena, CA (USA), 21-23 Mar 1991
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CADMIUM
METABOLISM
CALCIUM
BIOSYNTHESIS
ESTROGENS
BIOLOGICAL EFFECTS
BEAGLES
CALCIUM 45
OVARIES
SKELETON
SURGERY
TRACER TECHNIQUES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CALCIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DOGS
ELEMENTS
EVEN-ODD NUCLEI
FEMALE GENITALS
GONADS
HORMONES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MEDICINE
METALS
NUCLEI
ORGANS
RADIOISOTOPES
STEROID HORMONES
SYNTHESIS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550501 - Metabolism- Tracer Techniques