Cadmium acclimation and hormesis in Fundulus heteroclitus during fin regeneration

Journal Article · Tue Apr 01 00:00:00 EST 1986 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(86)80061-5· OSTI ID:5729413

Weis, P; Weis, J S

The authors have previously demonstrated that exposure to cadmium at 0.1 and 0.5 mg/liter will retard the rate of fin regeneration in Fundulus heteroclitus. Since there is a body of literature indicating that preexposure to low levels of metals may increase tolerance during subsequent exposure, these experiments were designed to investigate the effects of preexposure to cadmium, using fin regeneration as the parameter of effect. Fish were exposed for 1 week to 0.001, or 0.05 mg/liter Cd. Following this preexposure, the lower third of the caudal fin was amputated, and regrowth of the fins measured by ocular micrometer twice weekly for 2 weeks. During regeneration fish were maintained in either clean water (2.5% S, 23-25/sup 0/C) or in water with 0.1 mg/liter Cd. Fish newly placed in Cd (C ..-->.. 0.1 Cd) regenerated at the slowest rate, while the 0.01 ..-->.. 0.1 Cd group approached the growth of control fish regenerating in clean water, indicating a protective effect or acclimation brought about by the preexposure. The 0.05 ..-->.. 0.1 Cd group regenerated even more rapidly than controls, a phenomenon which has been termed hormesis and is believed to be due to an overcompensation by homeostatic regulatory mechanisms. In a second set of experiments in which regeneration took place in 0.5 mg/liter rather than 0.1 mg/liter, a protective effect of preexposure was again see, but no hormesis was observed. Uptake data indicated that preexposed groups took up less Cd than the groups not preexposed.

• Research Organization: New Jersey Medical School, Newark
• OSTI ID: 5729413
• Journal Information: Environ. Res.; (United States), Vol. 39:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
BIOLOGICAL REGENERATION
CADMIUM
TOLERANCE
TOXICITY
UPTAKE
FISHES
BIOLOGICAL ADAPTATION
ANIMALS
AQUATIC ORGANISMS
BIOLOGICAL RECOVERY
BODY
ELEMENTS
METALS
RECOVERY
TISSUES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)