Development of more efficacious Tc-99m organ imaging agents for use in nuclear medicine by analytical characterization of radiopharmaceutical mixtures

Technical Report · Mon Apr 01 00:00:00 EST 1991

OSTI ID:5706382

Heineman, W R

Capillary electrophoresis is being evaluated as a separation technique for analyzing Tc and Re diphosphonate radiopharmaceuticals. Advantages compared with currently used HPLC techniques include greater resolving power, smaller sample size and more rapid separations. Feasibility has been demonstrated with electropherograms obtained on a Re-HEDP sample. The Tc-PAA complexes in a radiopharmaceutical mixture were found to be unaffected by injection into a Sprague Dawley rat. This was determined by HPLC analysis of the rat's urine, which contained the same complexes as were in the injected sample. Proton NMR spectra have been obtained for samples of Tc-MDP and Re-MDP in order to provide structural information about these complexes. An in vivo sensor is being developed for a brain perfusion agent. Polymer coatings are being explored to extract the brain perfusion agent in order to enhance sensitivity for a microelectrode-based sensor. 4 refs., 2 figs.

• Research Organization: Cincinnati Univ., OH (USA). Dept. of Chemistry
• Sponsoring Organization: USDOE; USDOE, Washington, DC (USA)
• DOE Contract Number: FG02-86ER60487
• OSTI ID: 5706382
• Report Number(s): DOE/ER/60487-5; ON: DE91012282
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
RADIOPHARMACEUTICALS
ELECTROPHORESIS
TECHNETIUM COMPLEXES
SYNTHESIS
BRAIN
DIAGNOSTIC USES
ELECTROCHEMISTRY
ELECTRODES
IMAGES
LIQUID COLUMN CHROMATOGRAPHY
METABOLITES
NUCLEAR MAGNETIC RESONANCE
NUCLEAR MEDICINE
PROGRESS REPORT
RHENIUM
STRUCTURAL CHEMICAL ANALYSIS
TECHNETIUM 99
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
CHEMISTRY
CHROMATOGRAPHY
COMPLEXES
DOCUMENT TYPES
DRUGS
ELEMENTS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAGNETIC RESONANCE
MEDICINE
METALS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RESONANCE
SEPARATION PROCESSES
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENTS
USES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550501 - Metabolism- Tracer Techniques