Radiopharmaceutical dosimetry in the standard newborn: a model
While there has been an abundance of literature dealing with the absorbed radiation dose from administered radiopharmaceuticals in the standard 70-kg man, a deficiency exists in the availability of this information in the newborn and pediatric population. Direct absorbed dose extrapolation from adult to pediatric patients is not possible. Because of the compactness of the newborn and pediatric human, the absorbed dose per unit may be considerably higher than in the adult population. Before radiopharmaceuticals, particularly investigative new drugs (IND), can be utilized in this age group this data must be available for all the appropriate institutional committees and regulatory bodies. Following the format of the MIRD Committee, a standard newborn model has been constructed. Application of this model allows the user to develop S tables of absorbed dose per cumulated activity for selected radionuclides. This methodology provides for an extension of the tables as presented in NM/MIRD Pamphlet No. 11 for use in this population. Utilizing nuclear data presented in other NM/MIRD pamphlets, this model can be used for dosimetric calculations for most radionuclides after radiobiokinetic data have been collected.
- Research Organization:
- Univ. of Nebraska Medical Center, Omaha
- OSTI ID:
- 5705802
- Report Number(s):
- CONF-801082-; TRN: 82-003976
- Journal Information:
- HHS Publ. (FDA) (U.S.); (United States), Vol. 81-8166; Conference: ORAU radiopharmaceutical dosimetry symposium, Oak Ridge, TN, USA, 6 Oct 1980
- Country of Publication:
- United States
- Language:
- English
Similar Records
MIRD Pamphlet No. 21: A Generalized Schema for Radiopharmaceutical Dosimetry-Standardization of Nomenclature
A revised dosimetric model of the adult head and brain
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
DOSIMETRY
MATHEMATICAL MODELS
NEONATES
RADIATION DOSE DISTRIBUTIONS
RADIOPHARMACEUTICALS
TISSUE DISTRIBUTION
BIOLOGICAL MODELS
PATIENTS
RADIATION DOSES
RADIONUCLIDE KINETICS
DISTRIBUTION
DOSES
DRUGS
LABELLED COMPOUNDS
560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)
550601 - Medicine- Unsealed Radionuclides in Diagnostics