Derivation of a reference dose for a complex petroleum hydrocarbon mixture
- ChemRisk - A Division of McLaren/Hart Engineering, Irvine, CA (United States)
- ENVIRON Corp., Emeryville, CA (United States)
Petroleum hydrocarbon mixtures pose a challenge in assessing potential health effects associated with environmental exposures through impacted media. Two components of risk assessment that must be addressed when evaluating these mixtures are toxicity and environmental fate. In this paper, we focus on issues regarding toxicity. Specifically, we have developed a methodology to derive a reference dose (RfD) for a complex petroleum hydrocarbon mixture referred to as diluent. Diluent is a solvent used in the production of crude oil and is composed of hydrocarbons in the middle distillate range. Two conservative approaches to developing a reference dose for diluent are presented. Both involve separating the diluent into carbon number ranges (e.g., diluent consists of hydrocarbons containing between 5 carbons and greater than 21 carbons, so, the mixture can be divided into mixtures of hydrocarbons having 5 carbons, 6-11 carbons, etcetera) and assigning each range a representative RfD. In the first approach, the representative RfD for each range is that of one specific chemical within the range (e.g., the reference dose for the C{sub 5}-C{sub 8} carbon range is that of n-hexane). In the second approach, the RfD dose for each range is that of a mixture of chemicals representative of each carbon number range (e.g., the RfD for the C{sub 6} to C{sub 11} carbon range is that of mineral spirits). The RfD for each carbon range is then multiplied by the percent of diluent in the corresponding range and the products are added to arrive at a final RfD. The RfD for diluent using the first approach is estimated at 2 mg/kg-day and that using the second approach is estimated at 1 mg/kg-day.
- OSTI ID:
- 569915
- Report Number(s):
- CONF-971116-; TRN: 98:000778-0017
- Resource Relation:
- Conference: 1997 petroleum hydrocarbons and organic chemicals in ground water: prevention, detection, and remediation conference, Houston, TX (United States), 12-14 Nov 1997; Other Information: PBD: 1997; Related Information: Is Part Of Proceedings of the 1997 petroleum hydrocarbons & organic chemicals in ground water: Prevention, detection, and remediation; PB: 811 p.
- Country of Publication:
- United States
- Language:
- English
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