SAS probit analysis for cadmium mortality
In the quantitation of heavy metal effectiveness it is useful to compute the median lethal dose (LD/sub 50/) to the exposed population. The computerized Statistical Analysis System (SAS) of probit analysis is particularly useful in analyzing dose-response data because it is more accurate than the graphical methods currently in use and, in addition, provides fiducial limits with its estimates. Acute and chronic cadmium mortalities of yound adult male and female Sprague-Dawley rats were determined by the SAS probit analysis. When male and female rats were administered comparable doses of cadmium chloride, based on individual body weights, males were more susceptible. A plausible explanation for this greater sensitivity of males to the heavy metal is testicular necrosis. The acute LD/sub 50//sub (30 days)/ value for males was 5.99 mg Cd/kg body wt, with 95% fiducial limits of 4.71-7.54 mg Cd/kg body wt, as compared to 7.13 (5.18-8.85) mg Cd/kg body wt for females. When multiple (chronic doses of cadmium were injected, LD/sub 50//sub (30 days)/ values were 4.25 (3.42-5.05( mg Cd/kg body wt and 5.14 (4.42-5.92) mg Cd/kg body wt for males and females, respectively. Chronic LD values indicate an increase in effectiveness of dose as time of injections was protracted.
- Research Organization:
- Texas Woman's Univ., Denton
- OSTI ID:
- 5695660
- Journal Information:
- Environ. Res.; (United States), Vol. 29:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CADMIUM
BIOLOGICAL EFFECTS
DOSE-RESPONSE RELATIONSHIPS
CADMIUM CHLORIDES
LETHAL DOSES
MORTALITY
NECROSIS
RATS
STATISTICS
TESTES
ANIMALS
BODY
CADMIUM COMPOUNDS
CADMIUM HALIDES
CHLORIDES
CHLORINE COMPOUNDS
DOSES
ELEMENTS
GONADS
HALIDES
HALOGEN COMPOUNDS
MALE GENITALS
MAMMALS
MATHEMATICS
METALS
ORGANS
PATHOLOGICAL CHANGES
RODENTS
VERTEBRATES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)