Proton beam irradiation and hyperthermia. Effects on experimental choroidal melanoma

Journal Article · Sun Dec 01 00:00:00 EST 1985 · Arch. Ophthalmol. (Chicago); (United States)

DOI:https://doi.org/10.1001/archopht.1985.01050120096028· OSTI ID:5688192

Riedel, K G; Svitra, P P; Seddon, J M; Albert, D M; Gragoudas, E S; Koehler, A M; Coleman, D J; Torpey, J; Lizzi, F L; Driller, J

Ultrasonically induced hyperthermia (4.75 MHz) and proton irradiation (160 meV) were evaluated alone and combined to treat experimental choroidal melanoma in 58 rabbit eyes. Threshold tumoricidal doses were established for each modality. Therapy was performed combining subthreshold doses of heat and radiation. Focused ultrasonic energy via an external beam was found to deliver well-localized heat to an intraocular tumor. Ectopic temperature elevations due to soft-tissue-bone interfaces were alleviated by modifying beam alignment. The results indicate that hyperthermia (43 degrees C for one hour) potentiated the tumoricidal effects of radiation, while sparing normal ocular structures. Therefore, we believe that experimental hyperthermia is suitable as an adjuvant treatment modality. This shows that ultrasound hyperthermia has the potential to increase the efficacy of proton irradiation by lowering radiation doses and thus decreasing posttreatment ocular morbidity in human intraocular malignancies.

• OSTI ID: 5688192
• Journal Information: Arch. Ophthalmol. (Chicago); (United States), Vol. 12
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
EXPERIMENTAL NEOPLASMS
COMBINED THERAPY
MELANOMAS
RADIOTHERAPY
TEMPERATURE EFFECTS
UVEA
BIOLOGICAL MODELS
HAMSTERS
HYPERTHERMIA
PROTON BEAMS
PROTONS
RABBITS
RADIATION DOSES
ANIMALS
BARYONS
BEAMS
BODY
BODY AREAS
BODY TEMPERATURE
DISEASES
DOSES
ELEMENTARY PARTICLES
EYES
FACE
FERMIONS
HADRONS
HEAD
MAMMALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEON BEAMS
NUCLEONS
ORGANS
PARTICLE BEAMS
RADIOLOGY
RODENTS
SENSE ORGANS
THERAPY
VERTEBRATES
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