The effect of ethanol and/or acetaldehyde on the incorporation of U/sup 14/C-glucose into human umbilical artery lipids

Journal Article · Fri Jan 01 00:00:00 EST 1982 · Artery (Fulton, Mich.); (United States)

OSTI ID:5687503

Dupont, J; Nelson, A W; Clow, D J

The effect of ethanol, acetaldehyde and a combination of ethanol and acetaldehyde added in vitro was determined on their abilities to alter conversion of glucose to lipid. When human umbilical arteries were perfused with acetaldehyde at a 0.5% concentration, a significant reduction (p less than 0.05) of /sup 14/C incorporation into lipid was observed. This reduction was found to be the result of depressed incorporation of glucose into phospholipid (PL) and triacylglycerides (TG). Acetaldehyde at a concentration of 0.25% appeared to depress incorporation; however, this was not significant. Acetaldehyde plus ethanol at final equal concentrations of 0.25%, 0.5% and 1.0% had no effect on incorporation of U/sup 14/ C-glucose into lipid. Ethanol at concentrations of 0.5%, 0.25% and 0.125% had no effect on the incorporation of U/sup 14/ C-glucose into lipid. The study suggests that acetaldehyde can depress the conversion of glucose into umbilical artery lipids. However, acetaldehyde in the presence of equal concentrations of ethanol does not exhibit this ability to depress conversion of glucose to lipids suggesting some cellular counter effect of these two agents.

• Research Organization: Department of Food Science, Colorado State University, Fort Collins
• OSTI ID: 5687503
• Journal Information: Artery (Fulton, Mich.); (United States), Vol. 11:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ACETALDEHYDE
BIOLOGICAL EFFECTS
CARBON 14 COMPOUNDS
TRACER TECHNIQUES
ETHANOL
GLUCOSE
METABOLISM
ARTERIES
BIOSYNTHESIS
LIPIDS
UPTAKE
ALCOHOLS
ALDEHYDES
BLOOD VESSELS
BODY
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
HEXOSES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
SACCHARIDES
SYNTHESIS
550501* - Metabolism- Tracer Techniques