Cognitive performance correlates with cerebrovascular impairments in multi-infarct dementia

Journal Article · Thu May 01 00:00:00 EDT 1986 · J. Am. Geriatr. Soc.; (United States)

DOI:https://doi.org/10.1111/j.1532-5415.1986.tb04318.x· OSTI ID:5687390

Judd, B W; Meyer, J S; Rogers, R L; Gandhi, S; Tanahashi, N; Mortel, K F; Tawaklna, T

Cerebral blood flow (CBF) was measured by the /sup 133/Xe inhalation method in patients with multi-infarct dementia (MID, N = 26), Alzheimer's dementia (AD, N = 19), and among age-matched, neurologically normal, healthy volunteers (N = 26). Cognitive performance was assessed in all subjects using the Cognitive Capacity Screening Examination (CCSE). Cerebral vasomotor responses were calculated from differences in values of mean hemispheric gray matter blood flow (Delta CBF) measured during inhalation of 100% oxygen (hyperoxia) compared with CBF measured while breathing room air. Significant correlations were found between CCSE performance and vasomotor responsiveness in patients with MID (P less than .01), but not in patients with AD or in neurologically normal volunteers. Loss of vasomotor responsiveness is an indicator of cerebrovascular disease with rigidity and/or loss of reactivity of cerebral vessels, which impairs cerebrovascular responses to situational demands and predisposes to cerebral ischemia. Loss of cerebral vasomotor responsiveness among MID patients, which is a biologic marker of cerebrovascular disease, provides confirmatory evidence of the vascular etiology of MID and assists in separating MID from AD patients.

• Research Organization: Veterans Administration Medical Center, Houston, TX
• OSTI ID: 5687390
• Journal Information: J. Am. Geriatr. Soc.; (United States), Vol. 5
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
BRAIN
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VASOCONSTRICTION
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550901* - Pathology- Tracer Techniques